Table 2.

Role of adrenergic receptors in the brain. The role of adrenergic receptors such as α or β adrenergic receptors (ARs) in different brain regions of Alzheimer’s disease (AD) mice models is summarized.

Description	Outcomes or Role	References
Blockade of α1 ARs in APP23 transgenic mice model of AD	Impairment in cognitive functions	[94]
β2 AR in PFC of APP/PS1 transgenic mouse model	Alteration in Amyloid Precursor Protein (APP) processing and mediation of Aβ-induced tau pathology	[97]
α2A AR in cerebral cortex of AD transgenic mice model	Regulation of APP proteolytic processing and Aβ production and secretion	[98]
Blockade of β ARs in APP mouse model	Impairment in cognitive functions, and behavior. Inducing inflammation with chronic blockade of these receptors	[103]
β1 AR activation in hippocampal pyramidal neurons in mice	Role in contextual and spatial memory consolidation and retrieval	[100,101,102]