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. 2021 Jan 22;22(3):1096. doi: 10.3390/ijms22031096

Figure 5.

Figure 5

CD38-dependent expansion and activation of functional CD38-CAR iNKT cells. CD38-CAR iNKT cells with different costimulatory domains and mock-transduced cells were weekly re-stimulated with irradiated CD38+UM9 cell line at a CAR+iNKT:/target ratio of 3:1, starting 4 days after transduction. (A) Depicted are the calculated numbers of total iNKT cells (left) and of CAR + iNKT cells (right). (B) The percentage of CAR+iNKT cells in the culture at Week 2 and Week 6. (C) Cytotoxic activity of CD38-CAR vs mock-transduced iNKT cells towards a CD1d negative primary MM cell sample at the end of the cultures. (D) Graphs depict the expression of PD-1, CD57, and CD39 on iNKT cells. Similar results were observed in a second independent experiment.