Figure 1.
Representative nano CT isosurface renderings and histology of Alpl+/+ and Alpl−/− ossicles after eight weeks of implantation. (A–F), Nano CT isosurface renderings of Alpl+/+ (A–C) and Alpl−/− (D–F) ossicles after 8 weeks of implantation. (G–N), Histologic stains of Alpl+/+ (G–J) and Alpl−/− (K–N) ossicles after 8 weeks of implantation. (G–J), Alpl+/+ ossicles and (K–N), Alpl−/− ossicles. Mason’s trichrome (G,H,K,L); hematoxylin and eosin (I,M); alkaline phosphatase (J,N) stains. Note lack of bone trabeculae in Alpl−/− ossicles as seen by histology and isosurface images.