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. 2021 Jan 24;22(3):1140. doi: 10.3390/ijms22031140

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TNAP deficiency decreases muscle strength and impairs motor coordination. Muscle strength and motor coordination tests were carried out in Alpl^+/+ (n = 11) and Alpl^−/− (n = 13) littermates at 14 days old. (A) Grip strength is significantly decreased in Alpl^−/− as compared to Alpl^+/+ mice. (B) The ratio of grip strength/body weight is significantly decreased in Alpl^−/− as compared to Alpl^+/+ mice. (C) Alpl^−/− mice fell off the inverted screen significantly earlier as compared to Alpl^+/+ mice. (D) Alpl^−/− mice fell off the horizontal bar significantly earlier as compared to Alpl^+/+ mice. *** p < 0.001, statistical significance between genotypes.