Figure 1.

Downregulation of IQGAP1 in advanced PCs. Primary PCs with low Gleason scores 6–7 (GS 6–7) and high GS 9–10 (see Table S1 for details) were stained for IQGAP1 by IHC. Typical images (A) and quantification (B), means ± SD (standard deviation), are graphed. **: p < 0.01 by 2-tailed Mann-Whitney test. Images were analyzed using Aperio ImageScope software (Leica Microsystems Inc., Concord, Ontario, Canada); staining intensity was quantified as Histo-scores (HScores). Stromal regions (control) were used as baseline when analyzing final H-score for each sample.