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Degradation of fibrin in presence of CPC scaffolds. The concentration of fibrin degradation products in supernatants of rMSC-laden and rMSC-free biphasic CPC-fibrin constructs was measured over time, a cumulative release curve is shown (A) (mean ± SD, n = 5). Stereomicroscopical images clearly revealed that fibrin was only degraded in presence of rMSC, whereas cell-free scaffolds showed no signs of degradation (B). Red arrows tag the fibrin gel. Scale bars represent 2 mm.
