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Epithelial–mesenchymal transition (EMT) by mitochondria.TCA: tricarboxylic acid; OXPHOS: oxidative phosphorylation. Mitochondrial metabolites are accumulated upon mutation of the indicated TCA cycle enzymes which activates the EMT. In cancer cells, the TCA cycle not only serve to produce reducing equivalents to fuel the electron transport chain, but also to generate biosynthetic intermediates that are necessary for cell proliferation and migration.
