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Anatomical structures of brain vasculature. (a) The glymphatic system: xenobiotics circulation, diffusion and efflux along perivascular spaces after intrathecal administration. (b) Cross section of a brain vessel: xenobiotics circulate along perivascular spaces of blood vessels. A: astrocyte, regulator of the hydrostatic pressure by water exchanges; AQP4: aquaporin 4; P: pericyte; EC: endothelial cell; PVS: perivascular space; B: blood. (Images modified from © SMART/CC-BY-3.0).
