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177Lu-labeling of PNA-based probes and in vitro stability.
| Construct | Radiochemical Yield, % | Radiochemical Yield after EDTA Treatment, % | Isolated Yield, % | Radiochemical Purity, % | Stability (×500 EDTA), 37 °C, 1 h |
|---|---|---|---|---|---|
| ZHER2:342-SR-HP15 | 78.5 ± 6.4 | 65.0 ± 7.1 | 66.0 ± 1.4 | 100 ± 0 | 100 ± 0 |
| HP16 | 99.8 ± 0.3 | 99.2 ± 1.4 | - | 99.2 ± 1.4 | 100 ± 0 |
| HP17 | 99.0 ± 1.7 | 98.8 ± 2.0 | - | 98.8 ± 2.0 | 100 ± 0 |
| HP18 | 97.5 ± 2.0 | 98.4 ± 2.7 | - | 98.4 ± 2.7 | 100 ± 0 |
| HP2 | 73.2 ± 0.2 | 69.6 ± 2.6 | 51.5 ± 9.2 | 100 ± 0 | - |
