Table 4.
Biodistribution of new 177Lu-labeled secondary probes in BALB/C nu/nu mice bearing SKOV3 xenografts at 4 h p.i. without preinjection of a primary agent. The uptake is expressed as % ID/g and presented as an average value from 5 mice ± SD. One-way ANOVA with Bonferroni’s multiple comparisons test was performed to find significant differences.
| Uptake, % ID/g | |||
|---|---|---|---|
| Organ or Tissue | [177Lu]-HP16 | [177Lu]-HP17 | [177Lu]-HP18 |
| Blood | 0.007 ± 0.003 | 0.005 ± 0.001 c | 0.019 ± 0.006 b |
| Lung | 0.09 ± 0.02 | 0.07 ± 0.01 c | 0.12 ± 0.02 |
| Liver | 0.08 ± 0.01 | 0.08 ± 0.02 c | 0.11 ± 0.02 b |
| Spleen | 0.053 ± 0.008 | 0.06 ± 0.01 | 0.08 ± 0.02 |
| Kidney | 3.6 ± 0.6 | 4.5 ± 0.4 c | 9.1 ± 0.9 b |
| Tumor | 0.12 ± 0.03 | 0.08 ± 0.01 | 0.10 ± 0.01 |
| Muscle | 0.025 ± 0.004 | 0.023 ± 0.006 | 0.029 ± 0.003 |
| Bone | 0.051 ± 0.008 a | 0.036 ± 0.007 c | 0.07 ± 0.02 |
| GI * | 0.29 ± 0.06 | 0.86 ± 0.21 | 0.65 ± 0.34 |
| Carcass * | 1.0 ± 0.4 | 1.18 ± 0.43 | 1.17 ± 0.17 |
a Significant difference between [177Lu]Lu-HP16 and [177Lu]Lu-HP17; b significant difference between [177Lu]Lu-HP16 and [177Lu]Lu-HP18; c significant difference between [177Lu]Lu-HP17 and [177Lu]Lu-HP18; * data for the GI tract, with content and carcass, are presented as % of injected dose per whole sample.