Table 2.
Univariate and multivariable analyses of time to type of first recurrence and cancer specific survival.
| Potential Risk Factors | TDM | TILR | CSS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Level | n | Univariate HR (95% CI) | p | Multivariable HR (95% CI) | p | Univariate HR (95% CI) | p | Multivariable HR (95% CI) | p | Univariate HR (95% CI) | p | Multivariable HR (95% CI) | p | |
| Age | ≤70 >70 |
58 40 |
1.2 (0.7–2.1) |
0.602 | 1.3 (0.6–2.8) |
0.449 | 1.4 (0.9–2.1) |
0.156 | ||||||
| Sex | Male female |
50 48 |
0.7 (0.4–1.2) |
0.127 | 0.8 (0.4–1.7) |
0.627 | 0.8 (0.5–1.2) |
196 | ||||||
| CA19–9 (24 missing) | ≥200 <200 |
43 31 |
1.2 (0.6–2.2) |
0.623 | 1.0 (0.5–2.3) |
0.939 | 1.1 (0.7–1.8) |
0.601 | ||||||
| Tumour sizeon CT (1 missing) | ≥25 mm <25 mm |
39 58 |
1.4 (0.8–2.3) |
0.272 | 2.0 (1.0–4.) |
0.057 | 1.3 (0.8–2.0) |
0.241 | ||||||
| CTC | ≥1 none |
7 91 |
3.9
(1.7–8.8) |
0.001 |
2.9
(1.3–6.6) |
0.010 | All censored |
4.4
(2.0–9.8) |
<0.001 | 0.001 | ||||
| Neoadjuvant chemotherapy | Yes no |
4 94 |
1.2 (0.3–5.0) |
0.928 | 2.0 0.5–8.7) |
0.333 | 1.0 (0.4–3.7) |
0.964 | ||||||
| Venous resection | yes no |
36 62 |
0.5
(0.3–0.9) |
0.017 | eliminated | 1.6 (0.8–3.3) |
0.209 | eliminated | 0.8 (0.5–1.2) |
0.326 | eliminated | |||
| Adjuvant chemotherapy | Yes no |
62 36 |
0.8 (0.5–1.4) |
0.466 | 0.9 (0.4–1.9) |
0.735 | 0.7 (0.7–1.1) |
0.124 | ||||||
| pT | 1,2 3,4 |
3 95 |
0.7 (0.2–2.7) |
0.557 | All censored | 0.5 (0.1–1.9) |
0.300 | |||||||
| pN | 1 0 |
73 25 |
3.6
(1.7–7.3) |
0.001 |
3.0
(1.5–6.3) |
0.003 | 1.6 (0.7–3.6) |
0.226 | eliminated |
2.1
(1.2–3.5) |
0.004 |
2.0
(1.2–3.4) |
0.009 | |
| Grade | G3,4 G1,2 |
28 70 |
2.1
(1.2–3.6) |
0.007 |
1.8
(1.1–3.1) |
0.030 | 0.6 (0.2–1.7) |
0.336 | eliminated | 1.4 (0.9–2.1) |
0.184 | eliminated | ||
| R | 1 0 |
61 37 |
1.4 (0.8–2.3) |
0.212 | eliminated |
2.3
(1.0–5.0) |
0.040 |
2.3
(1.0–5.0) |
0.040 | 1.4 (0.9–2.2) |
0.128 | eliminated | ||
| Vascular infiltration | 1 0 |
65 33 |
1.7 (0.9–3.1) |
0.075 | eliminated | 0.9 (0.4–1.9) |
0.790 | eliminated |
1.6
(1.0–2.6) |
0.034 | eliminated | |||
| Perineural infiltration | 1 0 |
91 7 |
1.3 (0.5–3.7) |
0.588 | 2.7 (0.4–19.7) |
0.334 | 1.8 (0.7–4.6) |
0.185 | ||||||
Uni- and multivariable analysis of prognostic factors for TDM/TILR of resected PDAC patients. Univariate HR: Cox regression using single factors; Multivariable HR: Cox regression model with manual backwards elimination. Statistical significance assumed for p < 0.05, indicated by use of bold font. HR: Hassard ratio. CI: Confidence interval. CSS: cancer-specific survival, TDM: time to distant metastasis. TILR: time to isolated local recurrence.