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. 2021 Jan 25;22(3):1169. doi: 10.3390/ijms22031169

Figure 5.

Figure 5

Ibudilast prevents LPS-induced decreases in trabecular number in vivo. (A) Schematic representation of the experimental setup. (B,C) MicroCT three-dimensional image and transverse images of the bone defect site show that Ibudilast reversed the LPS-induced decrease in trabecular number in vivo. (D) Ibudilast not only promoted bone bridge formation but also promoted mature osteocyte formation. Data are presented as the mean ± standard error of the mean. Analyses were conducted with two-way analysis of variance followed by Bonferroni’s post-hoc test. * p < 0.05, ** p < 0.01. Abbreviations: LPS, lipopolysaccharide; Tb.N, trabecular number; Tb.Th, trabecular thickness; Tb.Sp, trabecular separation. Sham, n = 5; LPS, n = 7; and LPS + Ibudilast, n = 5.