Figure 3.

Enlarged view of the conformational transition of the ABL kinase domain between inactive DFG-out and active DFG-in states by activation loop phosphorylation and dephosphorylation. Structures of the DFG-out and -in forms are illustrated from PDB IDs 2HYY and 2V7A, respectively. The colors indicate the same regions shown in Figure 1. The orientation of the phenyl group of F382 is dynamically altered in the transition.