Table 3.

NK cell-derived exosomes in cancer progression.

NK Cell-Derived Exosomes’ Characteristics	Effect on Cancer Progression	Reference
Carry tumor suppressor miR-186	Directly downregulates MYCN and AURKA in neuroblastoma cells, which can potentially have a negative impact on their survival; miR-186 upregulation in NK cells resulted in the downregulation of TGFBR1 and TGFBR2 and, thus, impaired the TGFβ1-dependent inhibition of NK cells’ cytotoxicity.	[147]
Presented FasL, perforin and TNF-α	Decreased melanoma cells’ viability and capacity of proliferation	[148]
Exosomes loaded with NKG2D, TGFβ, granzyme B, perforin, killer-cell immunoglobulin-like receptors and PD-1	Promote the lysis of acute myeloid leukemia blast cells	[149]
N/A	NK cell-derived exosomes presented T cell leukemia, Burkitt lymphoma, metastatic breast adenocarcinoma, and metastatic melanoma human tumor cell lines	[150]
Expression of DNAM1	Cytotoxic activity of NK-derived exosomes against leukemia cells	[151]
Expression of perforin, FasL, granzyme A and B, and granulysin	Induction of target cells’ apoptosis	[152]