Figure 4.

Normalized extracellular adenylate kinase release per microgram protein following exposure of the sodium alginate encapsulated LS180 mini-tumor model to Sutherlandia frutescens aqueous extract and paclitaxel. The solid black line represents the untreated control, the black dashed line represents paclitaxel [IC₅₀], the orange line represents S. frutescens [IC₅₀] and the blue line S. frutescens [IC₅₀]/2. All data were normalized to the untreated control group (error bars = standard deviation; p < 3 for S. frutescens [IC₅₀]/2; n = 6 for S. frutescens [IC₅₀] and paclitaxel [IC₅₀]; * = statistically significant, p < 0.05 (one-way ANOVA followed by the Dunnett post-hoc test).