Table 2.
Comparing α- and β-sulfone derivatives for their matrix metalloproteinase 1 (MMP-1) activity [50].
| ||||||
| Ki (nM) | ||||||
| Compound | MMP-1 | MMP-2 | MMP-3 | MMP-9 | MMP-13 | Cmax |
| 11 (β-sulfone) | 800 | 0.4 | 17.5 | 1 | 0.6 | 1372 |
| 12 (α-sulfone) | 435 | ˂0.1 | 18.1 | 0.3 | 0.15 | 3119 |
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