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. 2021 Jan 22;22(3):1080. doi: 10.3390/ijms22031080

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Degenerative changes identified in adjacent uninjured NP tissue of Panx3^-/- mice following needle puncture. Representative X-ray image demonstrating caudal IVD 8/9 undergoing needle puncture injury. Dotted red circle highlights caudal IVD 9/10 of the motion segment distal to the site of injury. Representative safranin-O/fast green-stained mid-sagittal sections of uninjured caudal IVDs distal to the punctured IVDs, harvested 6-weeks after injury. Images are representative of n = 6 mice per group. Black arrow indicates accelerated NP degeneration marked by increased matrix density and reduced cellularity.