Table 1.
Major transporters and metabolic enzymes single nucleotide polymorphisms (SNPs).
| Gene | Protein | Allele | Nucleotide Change | Amino Acid Change | Location | RS Number |
|---|---|---|---|---|---|---|
| ABCB1 | Pgp | C1236T | C1236T | G412G | Exon 12 | 1128503 |
| ABCB1 | Pgp | G2677T/A | G2677T/A | A893S/T | Exon 21 | 2032582 |
| ABCB1 | Pgp | C3435T | C3435T | I1145I | Exon 26 | 1045642 |
| ABCG2 | BCRP | C421A | C421A | Q141K | Exon 5 | 2231142 |
| ABCC2 | MRP2 | C–24 T | C-24T | - | Promoter | 717620 |
| ABCC2 | MRP2 | G1249A | G1249A | V417I | Exon 10 | 2273697 |
| ABCC2 | MRP2 | C3972T | C3972T | I1324I | Exon 28 | 3740066 |
| UGT1A1 | UGT1A1 | UGT1A1*6 | G211A | G71R | Exon 1 | 4148323 |
| UGT1A1 | UGT1A1 | UGT1A1*28 | TA repeats | - | Promoter | 3064744 |
| UGT1A8 | UGT1A8 | UGT1A8*2 | C518G | A173G | Exon 1 | 1042597 |
| UGT1A8 | UGT1A8 | UGT1A8*3 | G830A | C227Y | Exon 1 | 17863762 |