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. 2021 Jan 23;13(3):421. doi: 10.3390/cancers13030421

Figure 2.

Figure 2

Distribution of T cell populations in MSS and microsatellite instability (MSI) GC tumors. (a) Relative and absolute frequency of MSS and MSI cases for each GC histological type. (b–f) Relative numbers of helper (b), cytotoxic T cells (c), Tregs (d), and Tregs normalized to helper T cells (e) and cytotoxic T cells (f), according to the MSI status and tumor histology. (g,h) Relative number of Tregs normalized to cytotoxic and helper T cells within the stroma (g) and tumor nest (h) areas of intestinal-type GC cases, according to MSI status. Relative number of Tregs, cytotoxic T cells, and helper T cells within the stroma (i) and tumor nest (j) areas of intestinal-type GC cases, according to MSI status. See Supplementary Figure S1 for a visual description of stroma and tumor nest areas. Box and whiskers represent median ± 10 to 90 percentile. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. Two-way ANOVA with Tukey’s/Sidak’s multiple comparisons test (b–f) and Mann–Whitney U test (g–j).