Table 1.
DNA repair genes whose expression is assiciated with prognostic value. Of 84 genes, 22 had prognostic value for both overall surivival (OS) and event free survival (EFS). NHEJ, non-homologous end joining; HRR, homologous recombination repair MMR, mismatch repair, FA, Fanconi anemia pathway; NER, Nucleotide excision repair; BER, Base excision repair; HR, hazard ratio.
| Pathway | Gene Name | Prognostic Value | HR (OS) | HR (EFS) |
|---|---|---|---|---|
| NHEJ | NSD2 | BAD | 3.7 | 2.8 |
| NHEJ | RIF1 | BAD | 3.2 | 2.3 |
| NHEJ | XRCC5 | BAD | 2.9 | 2.5 |
| NHEJ | PNKP | GOOD | 0.4 | 0.5 |
| NHEJ | POLL | GOOD | 0.3 | 0.5 |
| HRR/MMR | EXO1 | BAD | 3.9 | 1.8 |
| HRR/MMR | BLM | BAD | 2.9 | 1.8 |
| HRR/NER | RPA3 | BAD | 3.2 | 3.1 |
| HRR | RAD51 | BAD | 2.8 | 1.7 |
| HRR | MRE11 | BAD | 2.1 | 1.8 |
| HRR | ATM | GOOD | 0.5 | 0.6 |
| FA | RMI1 | BAD | 5 | 3 |
| FA | FANCI | BAD | 3.5 | 2.4 |
| FA | FANCA | BAD | 2.2 | 2.4 |
| NER | PCNA | BAD | 4.5 | 2.2 |
| NER/HRR | RPA3 | BAD | 3.2 | 3.1 |
| NER/BER/a-NHEJ | LIG3 | BAD | 2.6 | 2 |
| NER | POLD3 | BAD | 6.3 | 2.1 |
| NER | ERCC4 | BAD | 2.5 | 2.2 |
| NER | POLD1 | BAD | 2.4 | 2 |
| NER | ERCC1 | GOOD | 0.4 | 0.4 |
| NER | ERCC5 | GOOD | 0.5 | 0.5 |
| MMR/HRR | EXO1 | BAD | 3.9 | 1.8 |
| MMR | MSH2 | BAD | 2.7 | 1.6 |
| BER/NER/a-NHEJ | LIG3 | BAD | 2.6 | 2 |