Table 2.
Functions of serotonin in inflammation and immunity.
| Immune Cell | 5-HT Receptors | Response |
|---|---|---|
| Monocytes and Macrophages Dendritic cells |
1A, 1E, 2A, 3A, 4, 7 1B, 1E, 2A, 2B, 4, 7 |
Releases IL-6, 1β, 8/CXCL8, IFN-γ induced phagocytosis, T-cell stimulation, inhibits release of TNF- α, inhibits NK cell suppression. |
| Neutrophils | 1A, 1B, 2 | Inhibits tumor cell phagocytosis and oxidative burst. |
| T cells | 1A, 1B, 2A, 2C, 3A, 7 | Releases IL-2, 16 and IFN- γ, T-cell proliferation. |
| B cells | 1A, 2A, 3, 7 | |
| Endothelial cells | T-cell chemoattractant release, eNOS expression, inhibits leukocyte diapedesis | |
| Vascular smooth muscle cells | IL-6 synthesis, inhibits TNF-α induced expression of ICAM-1, VCAM-1, NO, NFκB. | |
| Microglia | 2B, 5A, 7 | Promotes injury-induced microglial motility, brain maturation |