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. 2021 Jan 27;22(3):1265. doi: 10.3390/ijms22031265

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The experimentally calibrated populations constructed with the Grandi et al. model for sinus rhythm (SR, blue) and atrial fibrillation (AF, red) conditions. (a,b) Representative traces of action potential (AP) models in SR and Pitx2-induced AF conditions. (c,d) Distributions of AP biomarkers (including dVdt_max, RMP, APD₅₀, and APD₉₀) under SR and Pitx2-induced AF conditions.