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The scheme of PNPs composed of exosome shell (EM) and PLGA core and modified by AS1411 aptamers (AS-EP) for tumor targeting: (A) Scheme of preparation AS-EP; (B) scheme of AS-EP extended circulation in blood. The PNPs were characterized by reduced uptake by macrophages, and by enhanced targeting to tumor cells with overexpressed nucleolin. Reproduced from Han et al. [219] with permission of American Chemical Society.
