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| Features | Antibody | Aptamer |
|---|---|---|
| Specificity | High | High |
| Size | Relatively high | Small |
| Stability | Unstable | Stable |
| Affinity | High | High |
| Immunogenicity | High | No humoral response |
| Potential target | Immunogenic molecules | Any target |
| Production | In vivo | In vitro |
| Cost | Expensive | Relatively cheap |
| Modification | Limited | Almost unlimited |
| Time to generate | ~6 months | ~3–7 weeks |
| Renal separation | Slow | Fast |
