Table 2.
Case–control analysis of absolute metabolic concentrations according to the cerebral regions: ASD vs. TD values for N-acetyl-aspartate (NAA), N-acetylaspartyl-glutamate (NAAG), glutamate + glutamine (Glx), glutamate (Glu), creatine (Cr), choline (Cho), and myoinositol (mI) (absolute concentrations are group means). Regions = anterior cingulate cortex and posterior cingulate cortex. p < 0.05 considered significantly different, while n.s. represents non-significant results.
| Brain Region [mM] | ASD (n = 22) | TD (n = 43) | p Value |
|---|---|---|---|
| Anterior Cingulated Cortex (ACC) | |||
| NAA + NAAG | 9.78 (0.49) | 10.44 (0.29) | p = 0.02 |
| NAA | 9.37 (1.36) | 9.91 (0.68) | n.s. |
| NAAG | 0.41 (0.27) | 0.55 (0.13) | p = 0.02 |
| Glx | 16.10 (6.87) | 15.19 (9.02) | n.s. |
| Glu | 12.10 (3.92) | 10.54 (5.64) | p = 0.02 |
| Cho | 2.08 (0.14) | 2.08 (0.13) | n.s. |
| Cr | 6.98 (1.56) | 7.40 (1.87) | n.s. |
| mI | 5.40 (0.78) | 5.25 (0.27) | n.s. |
| Posterior Cingulated Cortex (PCC) | |||
| NAA + NAAG | 10.80 (0.86) | 11.02 (0.68) | n.s. |
| NAA | 10.47 (1.39) | 10.68 (0.20) | n.s. |
| NAAG | 0.34 (0.53) | 0.32 (1.38) | n.s. |
| Glx | 13.87 (4.09) | 14.08 (2.15) | n.s. |
| Glu | 10.22 (3.19) | 10.71 (2.06) | n.s. |
| Cho | 1.55 (0.44) | 1.61 (0.38) | n.s. |
| Cr | 6.72 (0.90) | 6.99 (0.42) | n.s. |
| mI | 4.98 (0.68) | 5.13 (1.94) | n.s. |