Table 4.
Analytical performance of selected electrochemical aptasensors for PDGF.
| Strategy | Technique | LOD, M | Interference Studies |
Ref. |
|---|---|---|---|---|
| Sandwich assay based on MOS2/carbon aerogel composites | DPV | 0.3 × 10−12 | BSA, CEA, Hb, IgG | [208] |
| Structure-switching hairpin probe | CV | 2.67 × 10−12
(0.08 ng mL−1) |
PDGF-AA, PDGF-AB, IgG, BSA | [215] |
| VS2-GR coupled with Exo ΙΙΙ-aided signal amplification leaf like VS2 nanosheets | DPV | 0.03 × 10−12 | BSA, IgE, Thr, CEA | [216] |
| DPV | 0.4 × 10−12 | Hb, Thr, BSA | [217] | |
| A background current-eliminated Apt sensing platform | ACV | 0.334 × 10−12
(10 pg mL−1) |
PDGF-AA, PDGF-AB | [218] |
| Fe3O4@3D-rGO@plasma-polymerised (4-vinyl pyridine) nanocomposite | EIS | 0.98 × 10−12
(29.4 pg mL−1) |
Thr, IgG, Lyz, BSA | [219] |
| Co3(PO4)2 BSA-based aptasensor | EIS | 0.123 × 10−12
(3.7 pg mL−1) |
BSA, IgG, Lyz, Thr, PDFG-AA, PDGF-AB |
[220] |
| Exo ΙΙΙ-aided signal amplification strategy | DPV | 20 × 10−15 | Hb, BSA, IgG, CEA, BSA | [221] |
| Apt-functionalised MHCPP | FET | 1.78 × 10−15 | ATP, BSA, Cal, PDGF-AA | [209] |
| Apt based EGFET sensor RCA | EGFET | 8.8 × 10−12 | Not shown | [222] |
| Apt based dual signal amplification strategy using hydroxyapatite NPs | SWV | 1.67 × 10−15
(50 fg mL−1) |
AFP, CEA, IgG, HER2 | [223] |
| Sandwich Ab-Apt labelled ALP | SWV | 1.67 × 10−15
(50 fg mL−1) |
AFP, CEA, IgG, p53, HER2 | [224] |
| EXPAR | DPV | 52 × 10−15 | PDGF-AA, PDGF-AB | [225] |
| Carbon-based nanocomposites with Apt-Ag-NCs | EIS | 26.5 × 10−15
(0.82 pg mL−1) |
BSA, Thr, Lyz, IgG | [210] |
| Sandwich sensing system on 3D-IHC | Amp | 1.2 × 10−15
(0.03 pg mL−1) |
AA, UA, Gly, Glu | [226] |
| Aptasensor based on new structure of GNPs containing α-CD | SWV | 0.52 × 10−9 | BSA, PSA, HSA, p53 | [227] |
| Se-doped MWCNTs-Gr, Hem/G-quadruplex and Y shaped DNA-aided target-triggered | DPV | 27 × 10−15 | Thr, IgG, PSA | [213] |
| Apt-Functionalised 3D CNWs | FET | 1.78 × 10−15 | Cal, ATP, BSA | [214] |
Abbreviations: BSA—bovine serum albumin; CEA—carcinoembryonic antigen; Hb—haemoglobin; IgG—immunoglobulin G; Cal—calmodulin; AA—ascorbic acid; UA—uric acid; Gly—glycine; Glu—glucose; PDGF-AA—platelet-derived growth factor AA; PDGF-AB—platelet-derived growth factor AB; Exo III—Exonuclease III; IgE—immunoglobulin E; Thr—thrombin; Lyz—lysozyme; HER2—human epidermal growth factor receptor 2; AFP—alphafetoprotein; p53—cellular tumour antigen; SWV—Square Wave Voltammetry; EIS—electrochemical impedance spectroscopy; DPV—Differential Pulse Voltammetry; Amp—amperometry; FET—field-effect transistors; EGFET—extended-gate field-effect transistors; RCA—rolling circle amplification; AgNCs—silver nanoclusters; EXPAR—proximity hybridisation-induced isothermal; ACV—alternating current voltammetry; Apt-aptamer; Ab—antibody; HSA—human serum albumin; α-CD—Alpha-Cyclodextrin; ALP—alkaline phosphatase, PSA—prostate specific antigen; MHCPP—multidimensional hybrid conducting-polymer plate; MWCNTs—multiwalled carbon nanotubes; Gr—graphene; Hem—hemin; 3D CNWs—Three-Dimensional Carbon Nanowebs; ATP—Adenosine triphosphate; 3D-IHC—three dimensional inorganic hybrid composite.