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Temporal changes in intracellular calcium concentration ([Ca2+]i) in GT1-7 cells after exposure to PrP peptides. Temporal changes in fluorescence intensities corresponding to changes in [Ca2+]i of typical GT1-7 cells before and after exposure to each PrP peptide (20 µM). (a) PrP106–126; (b) PrP118–135; (c) scrambled PrP106–126. The arrow indicates the time of peptide addition.
