Figure 1.

Induction of cold and mechanical allodynia by a single intraperitoneal injection of oxaliplatin in mice. Three to 5 days after a single injection of oxaliplatin (6 mg/kg, i.p.), cold (a) and mechanical (b) allodynia were produced. Cold and mechanical allodynia were assessed by using the acetone drop and von Frey filament tests, respectively. Control mice were treated with a 5% glucose solution (i.p.). Oxa: oxaliplatin, D0: before the injection of oxaliplatin or 5% glucose, D3: 3 days after the injection of oxaliplatin or 5% glucose, D5: 5 days following the administration of oxaliplatin or 5% glucose. Control (5% glucose): n = 5, oxaliplatin: n = 5. * p < 0.05, ** p < 0.01, **** p < 0.0001 vs. Control with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.