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. 2021 Jan 21;26(3):548. doi: 10.3390/molecules26030548

Figure 2.

Figure 2

Time-dependent effect of Zingiber officinale on cold and mechanical allodynia induced by oxaliplatin (a,b). Time-dependent effect of Z. officinale in naïve mice (c,d). The effect of the oral administration of Z. officinale on cold (a) and mechanical (b) allodynia induced by a single oxaliplatin (6 mg/kg, i.p.) injection. Cold and mechanical allodynia were assessed by using the acetone drop and von Frey filament tests, respectively. Effect of Z. officnale administration (p.o.) on cold (c) and mechanical (d) stimuli in naïve mice. For cold and mechanical stimuli, acetone drop and von Frey filament tests were used, respectively. Distilled water (DW) was used as control. Control (Oxa + DW): n = 10, Oxa + Z. officinale 100 mg/kg: n = 7, Oxa + Z. officinale 300 mg/kg: n = 7, Oxa + Z. officinale 500 mg/kg: n = 7 (a,b). Control (Naïve + DW): n = 5, Naïve + Z. officinale 300 mg/kg: n = 5 (c,d). Baseline: before the injection of DW or Z. officinale, ns: non-significant, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. Control with two-way ANOVA followed by Sidak’s post-test for multiple comparisons.