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. 2021 Jan 24;22(3):1145. doi: 10.3390/ijms22031145

Figure 4.

Figure 4

4PYR is cytotoxic to HepG3 cells but not HEK293T. Cell viability after 72 h was assessed for HEK293T (A) and HepG3 (B) cells. Cells were exposed to 100 µM of 2PYR, 4PYR, or 6PYR for 24 h with pyridones removed and fresh medium replaced for an additional 48 h or continuously exposed to the pyridone isomers for 72 h. After 72 h, CellTiter-FluorTM viability assay was performed with results expressed as the mean fluorescence intensity relative to control, vehicle-treated cells (% Viability) ± standard error of the mean (SEM). Statistical significance: **** p < 0.0001.