Table 1.

Anti-inflammatory activity (CPE% values) of substituted 5-benzyliden-2-adamantylthiazole [3,2-b] [1,2,4] triazol-6(5H)-one.

Com.	R	CPE, a %	Pa b	Com	R	CPE a %	Pa b
1	H	40	0.407	14	4-NO2	42	0.409
2	3-OH	36	0.551	15	3-F	51	0.581
3	4-OH	37	0.554	16	4-F	56	0.566
4	2,4-OH	49	0.480	17	2-Br	67	0.274
5	2-OH, 3-OMe	58	0.485	18	3-Br	61	0.360
6	4-OH-3-OMe	46	0.503	19	4-Br	53	0.393
7	4-OH, 3,5-OMe	36	0.567	20	2-Cl	47	0.585
8	4-OMe	62	0.539	21	3-Cl	45	0.636
9	3,4-OMe	44	0.538	22	4-Cl	61	0.552
10	3,4,5-OMe	49	0.503	23	2,3-Cl	37	0366
11	4-N(CH3)2	55	0.407	24	2,4-Cl	37
12	2-NO2	40	0.409	25	2,6-Cl	32	0.585
13	3-NO2	15	-	indomethacin		47

a-CPE—carrageenan paw edema; b—probability to be active.