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Schematic overview of nutrient-induced GLP-1 secretion from L-cells. AC: adenylyl cyclase; DAG: diacylglycerol; GLP-1: glucagon-like peptide-1; GPCRs: G-protein coupled receptors; IP3: inositol trisphosphate; PLC-β: phospholipase C-β; PKA: protein kinase A; PKC: protein kinase C; PIP2: phosphatidylinositol 4,5-biphosphate; SGLT1: sodium/glucose co-transporter 1; TRPM5: transient receptor potential channel M5.
