Table 2.
Univariate analysis of prognostic value for mortality and tumor recurrence of inflammatory and nutritional biomarkers, pre- and post-LT, in the whole study population (n = 324).
| Mortality | HCC Recurrence | |||||
|---|---|---|---|---|---|---|
| Factors | HR | 95% Conf. Interval | p-Val | SHR | 95% Conf. Interval | p-Val |
| PLR | ||||||
| pre-LT | 1.004 | 1.002–1.006 | <0.001 | 1.005 | 1.002–1.007 | 0.001 |
| POD 1 | 1.001 | 0.999–1.002 | 0.399 | 1.001 | 0.999–1.003 | 0.196 |
| POD 3 | 1.001 | 0.998–1.003 | 0.354 | 1.001 | 0.998–1.004 | 0.384 |
| POD 5 | 1.001 | 0.998–1.004 | 0.295 | 0.999 | 0.996–1.003 | 0.982 |
| POD 7 | 1.003 | 1.001–1.005 | 0.012 | 0.999 | 0.996–1.002 | 0.769 |
| POM 3 | 1.003 | 1.001–1.005 | 0.003 | 1.001 | 0.998–1.003 | 0.333 |
| POM 6 | 1.005 | 1.004–1.008 | <0.001 | 1.003 | 1.001–1.006 | 0.018 |
| 1 year post-LT | 1.005 | 1.003–1.007 | <0.001 | 1.003 | 1.001–1.006 | 0.010 |
| NLR | ||||||
| pre-LT | 1.058 | 1.030–1.087 | <0.001 | 1.041 | 1.003–1.081 | 0.036 |
| POD 1 | 1.007 | 0.998–1.016 | 0.116 | 1.001 | 0.988–1.013 | 0.886 |
| POD 3 | 1.013 | 1.001–1.025 | 0.032 | 0.989 | 0.964–1.016 | 0.456 |
| POD 5 | 1.029 | 1.013–1.044 | <0.001 | 0.977 | 0.944–1.011 | 0.187 |
| POD 7 | 1.054 | 1.039–1.069 | <0.001 | 0.953 | 0.913–1.001 | 0.126 |
| POM 3 | 1.005 | 1.001–1.011 | 0.024 | 1.008 | 1.002–1.016 | 0.017 |
| POM 6 | 1.210 | 1.158–1.266 | <0.001 | 1.071 | 1.013–1.133 | 0.016 |
| 1 year post-LT | 1.058 | 1.030–1.087 | <0.001 | 1.157 | 1.007–1.331 | 0.040 |
| PNI | ||||||
| pre-LT | 0.988 | 0.962–1.014 | 0.382 | 1.018 | 0.982–1.057 | 0.315 |
| POD 1 | 0.952 | 0.915–1.000 | 0.145 | 1.029 | 0.975–1.086 | 0.288 |
| POD 3 | 0.984 | 0.942–1.027 | 0.473 | 0.999 | 0.943–1.058 | 0.977 |
| POD 5 | 0.980 | 0.941–1.020 | 0.326 | 1.006 | 0.944–1.072 | 0.840 |
| POD 7 | 0.956 | 0.916–0.998 | 0.044 | 1.009 | 0.948–1.073 | 0.776 |
| POM 3 | 0.943 | 0.911–0.976 | 0.001 | 1.005 | 0.954–1.059 | 0.834 |
| POM 6 | 0.911 | 0.874–0.949 | <0.001 | 1.008 | 0.963–1.054 | 0.722 |
| 1 year post-LT | 0.862 | 0.818–0.908 | <0.001 | 0.911 | 0.844–0.984 | 0.019 |
| CONUT | ||||||
| pre-LT | 0.956 | 0.876–1.044 | 0.326 | 0.936 | 0.837–1.047 | 0.251 |
| POD 1 | 1.071 | 0.944–1.216 | 0.282 | 0.850 | 0.719–1.005 | 0.158 |
| POD 3 | 1.003 | 0.910–1.106 | 0.944 | 0.970 | 0.850–1.108 | 0.662 |
| POD 5 | 1.006 | 0.902–1.122 | 0.904 | 1.001 | 0.833–1.204 | 0.987 |
| POD 7 | 1.158 | 1.017–1.319 | 0.026 | 0.959 | 0.812–1.133 | 0.628 |
| POM 3 | 1.211 | 1.075–1.365 | 0.002 | 1.002 | 0.832–1.207 | 0.980 |
| POM 6 | 1.335 | 1.195–1.493 | <0.001 | 0.951 | 0.797–1.135 | 0.582 |
| 1 year post-LT | 1.304 | 1.099–1.546 | 0.002 | 1.107 | 0.812–1.508 | 0.518 |
CONUT: controlling nutritional status, HR: hazard ratio, LT: liver transplantation, NLR: Neutrophil-to-Lymphocyte Ratio, PLR: Platelet-to-Lymphocyte Ratio, PNI: Prognostic Nutritional Index, POD: postoperative day, POM: postoperative month, SHR: subdistribution hazard ratio, bold numbers mark statistical significance.