Table 3.

Univariate and multivariate Cox analysis of prognostic factors for OS, in subgroup analysis of patients with overall survival (OS) > 1 year and no early HCC recurrence (n = 266).

	Univariate Analysis			Multivariate Analysis
Factors	HR	95% Conf. Interval	p-Val	HR	95% Conf. Interval	p-Val
Sex
- male	1
- female	0.850	0.340–2.123	0.728
Age	1.016	0.981–1.052	0.367
Pre-LT BMI	0.955	0.885–1.031	0.244
Pre-transplant diabetes	0.870	0.395–1.917	0.730
HIV positivity	1.115	0.481–2.590	0.798
HCV positivity	0.892	0.548–1.451	0.646
HBV positivity	0.870	0.4945–1.533	0.631
Alcohol abuse	1.523	0.915–2.533	0.105
MELD score	0.971	0.926–1.018	0.236
Child–Pugh score	0.839	0.585–1.205	0.343
Donor age	1.003	0.988–1.018	0.654
Donor BMI	0.987	0.925–1.054	0.706
Total ischemia time	1.001	0.999–1.003	0.303
Packed blood cells transfusion	1.044	1.004–1.085	0.029	1.058	1.004–1.117	0.040
Frozen fresh plasma transfusion	1.001	1.000–1.002	0.046
Pre-LT AFP	1.000	0.999–1.000	0.277
HCC recurrence	3.916	2.339–6.556	<0.001	5.428	2.859–10.307	<0.001
1 year post-LT PLR	1.005	1.002–1.007	<0.001
1 year post-LT NLR	1.332	1.194–1.486	<0.001	1.218	1.053–1.408	0.008
1 year post-LT PNI	0.863	0.814–0.915	<0.001	0.913	0.851–0.978	0.011
1 year post-LT CONUT	1.286	1.067–1.550	0.008

AFP: Alpha-Fetoprotein, BMI: body mass index, CONUT: controlling nutritional status, HBV: hepatitis B virus, HCC: hepatocellular carcinoma, HCV: hepatitis C virus, HIV: human immunodeficiency virus, HR: hazard ratio, LT: liver transplantation, MELD: Model for end-stage liver disease, NLR: Neutrophil-to-Lymphocyte Ratio, PLR: Platelet-to-Lymphocyte Ratio, PNI: Prognostic Nutritional Index, bold numbers mark statistical significance.