Table 4.
Univariate and multivariate analysis of prognostic factors for HCC recurrence, in subgroup analysis of patients with OS > 1 year and no early HCC recurrence (n = 266).
| Univariate Analysis | Multivariate Analysis | |||||
|---|---|---|---|---|---|---|
| Factors | SHR | 95% Conf. Interval | p-Val | SHR | 95% Conf. Interval | p-Val |
| Sex | ||||||
| - male | 1 | |||||
| - female | 2.093 | 0.844–5.190 | 0.211 | |||
| Age | 1.009 | 0.969–1.059 | 0.702 | |||
| Pre-LT BMI | 0.952 | 0.864–1.051 | 0.334 | |||
| Pre-transplant diabetes | 0.336 | 0.081–1.403 | 0.135 | |||
| HIV positivity | 1.042 | 0.327–3.316 | 0.944 | |||
| HCV positivity | 0.565 | 0.286–1.119 | 0.202 | |||
| HBV positivity | 1.917 | 0.959–3.830 | 0.165 | |||
| Alcohol abuse | 1.042 | 0.502–2.163 | 0.911 | |||
| MELD score | 0.939 | 0.857–1.028 | 0.177 | |||
| Child–Pugh score | 0.587 | 0.346–1.995 | 0.148 | |||
| Donor age | 0.994 | 0.974–1.015 | 0.622 | |||
| Donor BMI | 0.931 | 0.847–1.024 | 0.143 | |||
| Total ischemia time | 1.001 | 0.998–1.003 | 0.530 | |||
| Packed blood cells transfusion | 0.994 | 0.925–1.070 | 0.891 | |||
| Frozen fresh plasma transfusion | 0.999 | 0.999–1.000 | 0.363 | |||
| Pre-LT AFP | 1.000 | 0.999–1.001 | 0.341 | |||
| 1 year post-LT PLR | 1.004 | 1.001–1.006 | 0.009 | 1.005 | 1.001–1.006 | 0.008 |
| 1 year post-LT NLR | 1.166 | 1.009–1.349 | 0.038 | |||
| 1 year post-LT PNI | 0.900 | 0.830–0.975 | 0.011 | |||
| 1 year post-LT CONUT | 1.165 | 0.838–1.619 | 0.364 | |||
| Tumor number | 1.407 | 1.203–1.646 | <0.001 | 1.504 | 1.26–1.795 | <0.001 |
| Tumor max diameter | 1.284 | 1.116–1.478 | 0.001 | 1.344 | 1.145–1.578 | <0.001 |
| Edmonson–Steiner grading | 2.250 | 1.372–3.687 | 0.001 | 2.030 | 1.045–3.945 | 0.037 |
| Microvascular invasion | 4.859 | 2.338–10.100 | <0.001 | 3.511 | 1.605–7.681 | 0.032 |
AFP: Alpha-Fetoprotein, BMI: body mass index, CONUT: controlling nutritional status, HBV: hepatitis B virus, HCC: hepatocellular carcinoma, HCV: hepatitis C virus, HIV: human immunodeficiency virus, LT: liver transplantation, MELD: Model for end-stage liver disease, NLR: Neutrophil-to-Lymphocyte Ratio, PLR: Platelet-to-Lymphocyte Ratio, PNI: Prognostic Nutritional Index, SHR: subdistribution hazard ratio, bold numbers mark statistical significance.