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. 2021 Jan 29;22(3):1355. doi: 10.3390/ijms22031355

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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GATA6-overexpressing human CRC cells induce a stronger angiogenesis in vivo. The levels of two endothelial markers, CD31 and endomucin, in the tissues resected from the tumors grown from the parental (WT) and the GATA6-overexpressing clones derived respectively from HCT-116 (A) and HT-29 (B) cells transplanted into nude mice were analyzed by IHC staining using antibodies against CD31 and endomucin, respectively. (C) A proposed model of the angiogenesis-stimulatory effect of the stemness-high GATA6-overexpressing human CRC cells.