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The thermodynamic model of human UDG interaction with unspecific (A) and specific DNA containing dU nucleotide unit (B). The ΔG° value characterizing of five specific hydrogen bonds between UDG and U-base was evaluated to be approximately –1.3 kcal/mol (B), while unspecific electrostatic (■) and hydrophobic (★) interactions provide ΔG° = −5.9 kcal/mol (A) [27].
