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. 2021 Jan 29;22(3):1356. doi: 10.3390/ijms22031356

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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C21 lowers the pro-/anti-inflammatory microglia ratio. (A) C8B4 cell line was polarized toward an M1 phenotype with the incubation with both LPS and IFNγ. (B) C21 treatment improved the M1:M2 ratio in the LPS/IFNγ group, but only the absence of PD (interaction p = 0.04) (C) AT2R blockage with PD increased M1 microglia in both control and LPS/IFNγ treatment (interaction p = 0.001). (D) C21 treatment increased M2 cells in both control and LPS/IFNγ groups in the presence and absence of PD (interaction p= 0.003) (n = 4–6/group).