Table 1.
Clinical and disease characteristics of the study participants at inclusion.
| Total (n = 83) |
Control (n = 18) |
TNFi (n = 47) |
Non-TNFi (n = 18) |
p | |
|---|---|---|---|---|---|
| Age (years) | 58.5 ± 10.8 | 57.9 ± 10.8 | 56.9 ± 11.2 | 63.4 ± 8.4 | 0.089 |
| Female gender | 62 (74.7) | 11 (61.1) | 37 (78.7) | 14 (77.8) | 0.42 |
| Body mass index (kg/m2) | 26.9 ± 6.0 | 29.0 ± 6.8 | 26.7 ± 6.4 | 25.3 ± 3.2 | 0.21 |
| RA duration (years) | 3.7 [1.5; 11.3] | 0.3 [0.1; 3.8] | 4.2 [1.6; 12.0] | 5.4 [2.3; 14.8] | 0.007 |
| RF positive | 64 (77.1) | 13 (72.2) | 34 (72.3) | 17 (94.4) | 0.15 |
| Anti-CCP positive | 65 (78.3) | 15 (83.3) | 34 (72.3) | 16 (88.9) | 0.32 |
| Erosive RA | 35/79 (44.3) | 2/16 (12.5) | 23/45 (51.1) | 10 (55.6) | 0.016 |
| DAS28-ESR (n = 79) | 4.21 ± 1.09 | 4.18 ± 1.22 | 4.24 ± 1.03 | 4.16 ± 1.17 | 0.96 |
| DAS28-CRP (n = 80) | 4.08 ± 1.06 | 3.89 ± 1.35 | 4.13 ± 0.90 | 4.14 ± 1.15 | 0.92 |
| SDAI (n = 76) | 20 [13; 27] | 22 [15; 29] | 19 [15; 27] | 19 [13; 27] | 0.80 |
| CDAI (n = 76) | 19 [13; 26] | 21 [15; 29] | 17 [13; 25] | 19 [13; 26] | 0.44 |
| CRP (mg/L) | 8 [3; 17] | 6 [3; 17] | 10 [3; 18] | 6 [3; 23] | 0.39 |
| ESR (mm/h) (n = 81) | 17 [9; 28] | 17 [9; 25] | 15 [9; 30] | 18 [10; 34] | 0.93 |
| HAQ (n = 63) | 0.8 [0.5; 1.3] | 0.6 [0.4; 1.0] | 0.8 [0.6; 1.3] | 0.8 [0.4; 1.2] | 0.50 |
| VAS asthenia (mm) (n = 74) | 54.3 ± 26.1 | 51.7 ± 24.0 | 56.1 ± 25.6 | 52.6 ± 30.2 | 0.78 |
| RAID score (n = 61) | 5.24 ± 1.93 | 4.70 ± 1.25 | 5.36 ± 2.01 | 5.54 ± 2.39 | 0.19 |
| HAD-anxiety (n = 58) | 9.4 ± 3.9 | 8.3 ± 3.4 | 9.8 ± 4.4 | 9.5 ± 2.6 | 0.23 |
| HAD-depression (n = 59) | 7.2 ± 3.6 | 5.7 ± 3.8 | 7.7 ± 3.5 | 7.4 ± 3.4 | 0.13 |
| NSAIDs | 18 (21.7) | 4 (22.2) | 11 (23.4) | 3 (16.7) | 0.94 |
| Glucocorticoids | 37 (44.6) | 6 (33.3) | 18 (38.3) | 13 (72.2) | 0.027 |
| Methotrexate | 71 (85.5) | 16 (88.9) | 41 (87.2) | 14 (77.8) | 0.69 |
Data are presented as frequencies (associated percentages), as mean ± standard deviation, or as median [interquartile range]. CCP: cyclic citrullinated peptide; CDAI: clinical disease activity index; CRP: C-reactive protein; DAS28: disease activity score in 28 joints; ESR: erythrocyte sedimentation rate; HAD: hospital anxiety and depression scale; HAQ: health assessment questionnaire; NSAIDs: nonsteroidal anti-inflammatory drugs; RA: rheumatoid arthritis; RAID: rheumatoid arthritis impact of disease; RF: rheumatoid factor; SDAI: simple disease activity index; TNFi: tumor necrosis factor inhibitor; VAS: visual analogue scale.