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. 2021 Feb 5;19:21. doi: 10.1186/s12915-021-00962-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Mutability landscapes of amino acid substitutions in human ORs. a The number of original (left) vs. changed (right) amino acids due to missense substitutions. Amino acid bars are colored by physico-chemical properties of the residues (blue = hydrophobic, green = polar, dark cyan = aromatic, purple = negatively charged, red = positively charged, salmon, yellow and orange = special residues Cys, Pro, and Gly). b Categorization of all amino acid replacements according to substitution scores extracted from GPCRtm. The color scale bar on top indicates the range of score values for all computed changes (negative = red, positive = blue)