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. 2021 Jan 30;22(3):1378. doi: 10.3390/ijms22031378

Figure 1.

Figure 1

Spike timing-dependent LTP (t-LTP) can be induced with distinct low repeat spike timing-dependent plasticity (STDP) paradigms in 6-month-old adult mice. Whole cell patch clamp recordings (in current clamp) of timing-dependent LTP at SC-CA1 synapses of hippocampal slices from wild type mice. (A) One presynaptic EPSP paired with 1 postsynaptic action potential (AP, 6× 1:1, left inset) STDP paradigm used to induce canonical t-LTP. Typical recording from an individual cell for 6× 1:1 stimulation (indicated by arrow) induced t-LTP at SC-CA1 synapses. (B) One presynaptic EPSP paired with 4 postsynaptic APs (6× 1:4 protocol, left inset) STDP paradigm used to induce burst t-LTP. Typical recording from an individual cell for 6× 1:4 stimulation (indicated by arrow) induced t-LTP at the hippocampal SC-CA1 synapses. Insets: average EPSP before (1) and after t-LTP induction (2). Scale bars are shown in the respective insets.