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. 2021 Jan 30;22(3):1385. doi: 10.3390/ijms22031385

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of hyperglycemic condition and polyphenols on the inflammatory response of cerebral endothelial cells. Cells were exposed to normoglycemic condition (NG) or hyperglycemic condition (HG) in presence or not of each polyphenol-rich plant extract (10 μM GAE) or a pure polyphenol (10 μM). Relative expression of genes coding for IL-1β (A), IL-6 (B), TNF-α (C), COX-2 (D), iNOS (E) and IL-10 (F) was measured by RT-qPCR and normalized to GAPDH gene expression. Data are means ± SEM of three independent experiments (three cellular passages). *: p < 0.05 and **: p < 0.01 as compared to NG; ^#: p < 0.05, ^##: p < 0.01 and ^###: p < 0.005 as compared to HG.