TABLE 1.
Brewer's yeast‐induced hyperpyrexia inhibition report of MEPN and control samples in mice model
| Treatment | Dose (mg/kg b.w.; p.o.) | Normal rectal temperature (°F) | Rectal temperature (°F) after yeast administration | Rectal temperature (°F) after drug administration | ||
|---|---|---|---|---|---|---|
| 60 min | 120 min | 180 min | ||||
| TWN−80 | 10 ml/kg | 98.13 ± 0.32 | 103.32 ± 0.86 | 102.90 ± 0.34# | 102.33 ± 0.23# | 102.88 ± 0.36# |
| PCL | 100 | 98.50 ± 0.32 | 103.47 ± 0.33 | 99.14 ± 0.77*** | 98.88 ± 0.74*** | 97.82 ± 0.47*** |
| MEPN | 100 | 98.12 ± 0.88 | 103.77 ± 0.45 | 102.20 ± 0.66 | 102. 33 ± 0.47 | 102. 44 ± 23 |
| MEPN | 200 | 98.20 ± 0.45 | 104.04 ± 1.19 | 101.87 ± 0.47*** | 102.48 ± 0.38*** | 102.88 ± 1.15** |
| MEPN | 400 | 97.24 ± 0.54 | 104.44 ± 0.72 | 100.88 ± 0.84*** | 101.34 ± 0.88*** | 101.90 ± 0.74*** |
Effects of the MEPN on the hyperpyrexia inhibition test in mice (n = 6). Values are presented as mean ± SEM; one‐way analysis of variance (ANOVA) followed by Dunnett's test.
MEPN, methanol extract of the aerial part of Piper nigrum; PCL, paracetamol; TWN, 1% Tween‐80.
*
p < .05, **p < .01, and ***p < .001 are considered as significant compared with the control, where # is designated as control.