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. 2021 Feb 6;19:39. doi: 10.1186/s12951-021-00783-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Effects of PHBV content (a), PVA content (b), water–oil ratio (c) and homogenization time (d) on the preparation of PHBV-PTX-NPs by single factor design (n = 5). Three-dimensional response surface diagram of the interaction between water–oil ratio and PHBV content (e), the interaction between water–oil ratio and PVA content (f), the interaction between water–oil ratio and homogenization time (g), the interaction between PHBV content and homogenization time (h), the interaction between PVA content and homogenization time (i). PHBV, ploy (3-hydroxybutyrate-co-3-hydroxyvalerate); PVA, polyvinyl alcohol