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. 2021 Feb 6;19:39. doi: 10.1186/s12951-021-00783-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — a The stability of nanoparticles in PBS solution (mean ± SD, n = 3). b Hemolysis rate of different nanoparticles in vitro (mean ± SD, n = 3). c Effects of different nanoparticles on hemolysis in vitro. d Cytotoxicity against L02 cells after incubation with different concentrations of RGD-PDA-PHBV-NPs (PTX-free) for 48 h. In vitro drug release profile of PHBV-PTX-NPs (e), PDA-PHBV-PTX-NPs (f), RGD-PDA-PHBV-PTX-NPs (g) and raw PTX (h) in PBS with different pH value (n = 3). One way ANOVA, *p < 0.05; **p < 0.01, ***p < 0.001. PHBV, ploy (3-hydroxybutyrate-co-3-hydroxyvalerate); PTX, paclitaxel; PDA, polydopamine; NPs, nanoparticles