Table 2.

Univariable and multivariable Cox regression analyses of OS

	Univariable			Multivariable
	HR	95% CI	P	HR	95% CI	P
Age	1.01	(0.99,1.02)	0.308
BMI	0.98	(0.94,1.03)	0.418
Blood glucose
Normal	ref
Abnormal	1.08	(0.82,1.44)	0.574	1.04	(0.78,1.4)	0.781
Sex
Female	ref
Male	1.07	(0.81,1.41)	0.621
Smoking history
No	ref
Yes	1.14	(0.86,1.51)	0.358
Drinking history
No	ref
Yes	1.30	(0.94,1.81)	0.113
Diabetes
No	ref
Yes	1.05	(0.77,1.43)	0.771
Hypertension
No	ref
Yes	0.94	(0.69,1.27)	0.683
Allergic history
No	ref
Yes	1.22	(0.83,1.78)	0.314
Abdominal pain
No	ref
Yes	1.08	(0.8,1.47)	0.607
Back pain
No	ref
Yes	0.61	(0.4,0.92)	0.019	0.65	(0.42,1.03)	0.064
Anorexia
No	ref
Yes	0.86	(0.4,1.82)	0.689
Loss of appetite
No	ref
Yes	1.09	(0.82,1.43)	0.559
Loss of weight
No	ref
Yes	0.82	(0.62,1.09)	0.165
CA199
Normal	ref
37–1000	1.47	(1.02,2.12)	0.039	1.38	(0.94,2.01)	0.099
> 1000	1.84	(1.14,2.97)	0.013	1.86	(1.15,3.02)	0.012
Surgical procedure
Whipple	ref
Distal	1.26	(0.91,1.75)	0.161
Other	0.95	(0.44,2.02)	0.886
Location
Head	ref
Tail	1.21	(0.87,1.69)	0.253
Differentiation degree
Poor	ref
Moderate-high	0.79	(0.57,1.08)	0.144
AJCC8 staging
Stage I	ref
Stage II	1.05	(0.77,1.43)	0.753
Stage III-IV	1.30	(0.9,1.87)	0.162
Obstructive jaundice
No	ref
Yes	0.89	(0.68,1.17)	0.405

HR hazards ratio, CI confidence interval, BMI body mass index, CA cancer antigen, AJCC American Joint Committee on Cancer