Table 3.
Descriptive statistics of 26 clinical features of ICP individuals associated with/without 42 novel mutations
| Features | ICP with 42 novel mutations | ICP without 42 novel mutations | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Mean | SD | Min. | Max. | N | Mean | SD | Min | Max | P | |
| Basic information | |||||||||||
| Age (years) | 37 | 29.54 | 5.75 | 17.00 | 41.00 | 113 | 29.35 | 5.12 | 20.00 | 43.00 | 0.84 |
| Gestational age (days) | 34 | 254.03 | 22.68 | 196.00 | 290.00 | 110. | 260.04 | 18.05 | 204.00 | 290.00 | 0.06 |
| BMI (kg/m2) | 31 | 26.91 | 3.78 | 21.50 | 36.30 | 106 | 25.46 | 3.22 | 19.60 | 38.50 | 0.037 |
| Ion concentrations | |||||||||||
| K (mmol/L) | 34 | 4.04 | 0.30 | 3.60 | 4.90 | 106 | 3.99 | 0.32 | 3.20 | 4.80 | 0.44 |
| Na (mmol/L) | 34 | 137.71 | 2.70 | 133.00 | 143.00 | 105 | 137.36 | 2.27 | 132.00 | 143.00 | 0.47 |
| Cl (mmol/L) | 34 | 104.26 | 2.81 | 97.00 | 110.00 | 105 | 104.08 | 2.80 | 98.00 | 112.00 | 0.73 |
| Ca (mmol/L) | 34 | 2.31 | 0.15 | 2.09 | 2.80 | 105 | 2.31 | 0.16 | 2.00 | 2.90 | 0.86 |
| Mg (mmol/L) | 34 | 0.80 | 0.10 | 0.60 | 1.10 | 105 | 0.82 | 0.16 | 0.65 | 1.89 | 0.36 |
| P (mmol/L) | 34 | 1.10 | 0.17 | 0.72 | 1.50 | 105 | 1.13 | 0.18 | 0.70 | 1.60 | 0.51 |
| Routine blood tests | |||||||||||
| WBC (×109) | 36 | 8.21 | 1.97 | 4.94 | 13.36 | 113 | 8.66 | 3.07 | 4.37 | 24.23 | 0.30 |
| RBC (×109) | 36 | 3.89 | 0.44 | 3.24 | 4.98 | 113 | 3.82 | 0.41 | 2.96 | 4.81 | 0.39 |
| PLT (×109) | 36 | 196.33 | 62.49 | 87.00 | 412.00 | 113 | 198.81 | 63.24 | 75.00 | 377.00 | 0.84 |
| RDW.SD (fL) | 36 | 45.23 | 5.73 | 36.90 | 67.30 | 113 | 46.08 | 4.28 | 36.20 | 62.40 | 0.41 |
| Liver function indexes | |||||||||||
| ALT (U/L) | 37 | 90.81 | 126.35 | 3.00 | 452.00 | 113 | 95.77 | 125.18 | 4.00 | 595.00 | 0.83 |
| AST (U/L) | 37 | 76.35 | 88.34 | 12.00 | 359.00 | 113 | 83.08 | 97.35 | 12.00 | 456.00 | 0.71 |
| TBA (μmol/L) | 37 | 40.58 | 21.96 | 12.50 | 105.80 | 113 | 44.73 | 44.17 | 10.70 | 286.80 | 0.42 |
| TBIL (μmol/L) | 36 | 14.99 | 8.02 | 6.90 | 41.90 | 112 | 14.85 | 7.54 | 5.70 | 64.80 | 0.92 |
| DBIL (μmol/L) | 36 | 6.42 | 6.06 | 2.00 | 28.80 | 112 | 6.44 | 5.98 | 0.90 | 49.50 | 0.99 |
| IDBIL (μmol/L) | 36 | 8.57 | 4.41 | 3.50 | 26.90 | 112 | 8.43 | 3.30 | 2.90 | 23.40 | 0.86 |
| Lipid index | |||||||||||
| CHOL (mmol/L) | 35 | 6.35 | 1.66 | 3.35 | 10.50 | 108 | 6.40 | 1.43 | 3.75 | 10.95 | 0.87 |
| TG (mmol/L) | 35 | 3.78 | 1.65 | 2.11 | 10.44 | 108 | 3.54 | 1.54 | 1.20 | 11.10 | 0.44 |
| HDL (mmol/L) | 35 | 1.95 | 0.54 | 1.28 | 4.06 | 108 | 1.89 | 0.40 | 0.92 | 3.19 | 0.59 |
| LDL (mmol/L) | 35 | 2.68 | 1.41 | 0.19 | 5.96 | 108 | 2.89 | 1.21 | 0.13 | 6.28 | 0.39 |
| Uric acid (μmol/L) | 34 | 313.74 | 91.93 | 131.00 | 574.00 | 106 | 322.41 | 78.30 | 111.00 | 498.00 | 0.59 |
| Outcomes of pregnant women and newborns | |||||||||||
| Birth weight (kg) | 28 | 3.04 | 0.71 | 1.48 | 5.30 | 91 | 3.04 | 0.57 | 1.23 | 4.10 | 0.97 |
| Bleeding amount (ml) | 28 | 240.36 | 62.63 | 150.00 | 400.00 | 86 | 258.84 | 102.10 | 90.00 | 810.00 | 0.27 |
BMI body mass index, WBC white blood cell, RBC red blood cell, PLT platelet, RDW.SD red blood cell distribution width.SD, ALT alanine transaminase, AST aspartate transaminase, TBA total bile acids, TBIL total bilirubin, DBIL direct bilirubin, IDBIL indirect bilirubin, CHOL total cholesterol, TG triglyceride, HDL high-density lipoprotein, LDL low-density lipoprotein