Fig. 2.

GO and KEGG pathway analyses of significant differentially expressed mRNAs in HBE cells with or without CRISPR/Cas9-mediated p53-knockout. a Enrichment of top 30 mRNAs with differential expression, involved in various biological processes, cellular components, and molecular junctions. b KEGG pathway classification of differentially expressed mRNAs in p53-wt vs. p53-KO. c KEGG pathway classification of upregulated and downregulated mRNAs with significant differential expression in p53-wt vs. p53-KO. d Verification of selected randomly relative mRNA expression in the p53-KO group compared with that of the p53-wt group