Table 1.

Top 20 differential expressed genes/mRNAs in the p53-wt vs. p53-KO HBE cells post 12.5 µg/mL silica

Upregulated mRNA				Downregulated mRNA
Gene-ID	Fold change	Log2 (Fold)	p value	Gene-ID	Fold change	Log2 (Fold)	p value
ANKRD22	11.33825	3.503126	0.031888	SLC9B1	0.062922	− 3.99028	0.023555
GALNT16	5.9697	2.577658	0.015915	GOLGA8Q	0.067677	− 3.88519	0.040364
LGR5	5.805771	2.537488	0.00641	FAM19A5	0.068239	− 3.87326	0.033308
ITGA9	5.201689	2.37898	0.033195	LAIR2	0.07763	− 3.68725	0.035158
ELMOD1	5.045316	2.334945	0.038847	PLA2G2C	0.182084	− 2.45733	0.024876
GPT	4.512969	2.174077	0.042918	TNFRSF10C	0.215358	− 2.21519	0.018619
SCG3	4.258003	2.090177	0.028393	NEU4	0.227828	− 2.13399	0.040534
DEFA5	3.533064	1.82092	5.51E-05	VAV1	0.325185	− 1.62067	0.002011
DEFA6	3.417341	1.772874	0.002371	SHC2	0.36299	− 1.462	0.044092
CRYBB2	3.367854	1.751829	0.022507	LOC107985524	0.384776	− 1.37791	0.040135
JAKMIP2	3.267922	1.708373	0.022156	DLX2	0.394143	− 1.34321	0.022467
ZNF385B	3.169598	1.6643	0.018243	FNTB	0.437081	− 1.19403	0.039543
PRSS2	2.980291	1.575453	0.046668	COL8A2	0.456718	− 1.13063	0.006895
RNF103-CHMP3	2.964665	1.567869	0.00646	PSG8	0.458618	− 1.12464	0.015305
CHRNA1	2.764834	1.467193	0.009205	SLC35F3	0.465274	− 1.10385	0.041656
LRRC46	2.747	1.457857	0.04034	AS3MT	0.466297	− 1.10068	0.006206
ADCY4	2.725217	1.446371	0.008368	TREM2	0.47154	− 1.08455	0.000655
LIX1	2.71129	1.438979	0.041953	KCNMA1	0.479557	− 1.06023	0.002141
KCND3	2.666753	1.415084	0.015511	NANOS3	0.486488	− 1.03952	0.046132
SLC24A3	2.665332	1.414315	0.033314	SLC45A1	0.491734	− 1.35907	0.008291

p < 0.05 represents significantly changed