Table 3.

Integrative metabolic pathways analysis on results obtained from combined metabolomics and gene expression

Pathway name	Match status	p	Impact
Glyoxylate and dicarboxylate metabolism	10/92	0.000174	0.25455
Citrate cycle (TCA cycle)	8/142	0.000391	0.65854
Arginine biosynthesis	6/76	0.000679	0.30769
Butanoate metabolism	6/77	0.000899	0.32143
Alanine, aspartate and glutamate metabolism	6/82	0.002202	0.18333
Phenylalanine metabolism	5/50	0.003821	0.55
Biosynthesis of unsaturated fatty acids	6/106	0.005523	0.086957
Linoleic acid metabolism	5/64	0.027727	0.875
Propanoate metabolism	6/115	0.037239	0.19149
Glutathione metabolism	5/70	0.054837	0.18182
Glycine, serine and threonine metabolism	4/44	0.08738	0.38806
Fatty acid biosynthesis	4/70	0.13803	0.039062
d-Glutamine and d-glutamate metabolism	5/132	0.14551	0.22222
Synthesis and degradation of ketone bodies	4/79	0.14551	0.55556
Pyruvate metabolism	4/92	0.15422	0.18182
Tyrosine metabolism	4/114	0.15534	0.057471
Phenylalanine, tyrosine and tryptophan biosynthesis	3/57	0.15888	0.5
Alpha-Linolenic acid metabolism	4/117	0.29307	0.095238
Mucin type O-glycan biosynthesis	3/74	0.29307	0.14286
Arachidonic acid metabolism	4/148	0.36168	0.325
Tryptophan metabolism	3/90	0.37875	0.024096
Valine, leucine and isoleucine degradation	2/33	0.40123	0.08046
Glycerolipid metabolism	3/94	0.42493	0.088235
Terpenoid backbone biosynthesis	3/94	0.43402	0.057143
Ether lipid metabolism	3/98	0.46045	0.10526
Fatty acid degradation	2/43	0.47685	0.029703
Nicotinate and nicotinamide metabolism	3/124	0.48567	0.097561
Beta-Alanine metabolism	2/69	0.50185	0.046512
Pentose phosphate pathway	2/73	0.52518	0.021739
Lysine degradation	1/12	0.54015	0.0625
Porphyrin and chlorophyll metabolism	2/79	0.56871	0.019231
Sphingolipid metabolism	2/89	0.60199	0.035088
Glycolysis or Gluconeogenesis	2/90	0.62074	0.083333
Aminoacyl-tRNA biosynthesis	3/194	0.69254	0.013699
Fatty acid elongation	2/98	0.69748	0.027027